Residual nasopharyngeal carriage of vaccine-type pneumococci in a mature pneumococcal conjugate vaccine immunisation programme in Kenya

Poster, 11th International Symposium on Pneumococci and Pneumococcal Diseases, 15-19 April 2018, Melbourne, Australia.





In countries like the US and the UK with mature PCV programmes, good vaccine coverage, high efficacy against acquisition of vaccine-type (VT) pneumococci and durable herd protection have all resulted in reduced community transmission of VT pneumococci and near elimination of VT carriage in the population. In developing countries in Africa, PCVs have reduced VT-carriage prevalence in both vaccinated and unvaccinated populations. However, in Kilifi Kenya 5 years following PCV10 introduction with a catch-up campaign for all children <5 years, there is residual VT-carriage in approximately 10% of children <5 years old. We conducted carriage surveys in multiple sites across Kenya to obtain data that would aid in modelling and policy experiments to achieve near elimination of VT-carriage and high levels of herd protection. We found that there is high residual VT-pneumococcal carriage across Kenya 6 years post-PCV10 introduction among the under 5 years and older children (5-17 years), especially in the rural areas.