PCVIS is a project within the Epidemiology and Demography Department of the KEMRI-Wellcome Trust Research Programme (KWTRP), situated in Kilifi on the Kenyan coast. It is a partnership between KWTRP, London School of Hygiene & Tropical Medicine, Kenya Ministry of Health and Kilifi County Department of Health Services.
The PCVIS team
Professor Anthony Scott is the study’s Principal Investigator and leads a team of clinical, laboratory, field and operational staff. The project employs 100 staff, half of whom are Ministry of Health data clerks who enter vaccine data at health facilities in Kilifi County. Other team members are responsible for patient assessment and treatment in the adult wards of Kilifi County Hospital, radiology, laboratory analysis and field studies of nasopharyngeal carriage and serology. Operational and technical staff ensure the project runs efficiently, including data management, software development, finance, administration and logistics.
What makes PCVIS at the KEMRI-Wellcome Trust Research Programme unique?
Strongest surveillance system in Africa
PCVIS leverages the Kilifi Health and Demographic Surveillance System (KHDSS) run by the KEMRI Wellcome Trust Research Programme. The KHDSS continuously monitors population dynamics within a defined geographical area. Three times per year fieldworkers visit all homesteads to record births, deaths, pregnancies and migrations. With 285,000 (2017 figures) members, it is the largest surveillance system in Africa, and it renowned for its pioneering approaches and rigorous attention to data quality.
Linked population register, hospital admissions and laboratory records
What sets KHDSS apart from other demographic surveillance systems is that, since its inception in 2000, the system has linked the population register to hospital admissions and laboratory records at Kilifi County Hospital. The system can provide accurate information on disease incidence, disease-specific mortality rates and fertility rates and the data can be used to evaluate the impact of community-based interventions.
Vaccine Monitoring System
The introduction of the Kilifi Vaccine Monitoring System in 2008, which captures comprehensive records of vaccinations given to children at health facilities throughout Kilifi County, provides accurate vaccination coverage data. This can be linked to data on disease incidence to determine the effectiveness of PCV10.
KWTRP works closely with the Kilifi Sub County Health Management Team to implement PCVIS, and our results are shared with the Kenya Ministry of Health and internationally to inform vaccine policy in Kenya, the East Africa Region and worldwide. The PCVIS team at KWTRP believe that working collaboratively with policy makers is the best way of improving the use of research evidence in policymaking.